In other ties, Serie A champions Juventus face Europa League winners Atletico Madrid and Barcelona take on Olympique Lyonnais.
Pep Guardiola is pleased with the Premier League side's improvement and form over the past two months but will not make any premature comparison with his former clubs.
The two clubs will meet for the fourth time in five seasons in the first knockout phase of the Champions League
A round of Saturday's matches in Series A, La Liga and Bundesliga.
Runaway leaders Bayern Munich appeared to barely break sweat in a 4-0 win at Hanover 96 to chalk up their 14th Bundesliga win in a row on Sunday, leaving them a huge 19 points clear at the top.
News of all that's transpired on and off the football field
Eden Hazard finally scored his first goal for Real Madrid as his side beat second-placed Granada 4-2 in a highly entertaining game at the Santiago Bernabeu on Saturday to go four points clear at the top of La Liga.
Willian and Lionel Messi scored as Chelsea and Barcelona finished 1-1 after an absorbing first leg of their Champions League last 16 tie on Tuesday, while Bayern Munich, helped by two typical Thomas Mueller goals and two from Robert Lewandowski, romped to a 5-0 home win over Besiktas.
The Bundesliga was in danger of turning into another one-horse race on Sunday after second-placed VfL Wolfsburg were held 1-1 at home by promoted Paderborn, leaving titleholders Bayern Munich nine points clear at the top.
In other matches, VfL Wolfsburg edged past Hertha Berlin 2-0; promoted Ingolstadt snatched a last-gasp 1-0 win at Werder Bremen
Monaco's firepower was far too hot to handle for Olympique de Marseille as the Principality side moved top of the French Ligue 1 standings with a 4-0 home win on Saturday.
Undefeated Bayern Munich stumbled to a 0-0 draw at Borussia Moenchengladbach on Sunday that ended a four-game winning streak in the league but they remain four points clear at the top.
Atletico Madrid secured a hard-fought 2-1 home victory over Real Betis in La Liga on Sunday thanks to an own-goal by Rui Silva and a header by Alvaro Morata as Diego Simeone's side ended a three-game winless run in all competitions.
News of all that's transpired on and off the football field
Bayern Munich continued their winning run on Saturday by beating fading champions VfL Wolfsburg 3-1 to draw level on points with Bayer Leverkusen at the top of the Bundesliga.
Barcelona and Bayern Munich maintained dominance of their respective leagues but there was a shock for French Ligue 1 leaders Paris St Germain who lost to end a nine-match unbeaten run.
Bundesliga champions Bayern Munich suffered their first league defeat in 18 months when they slumped to a 1-0 loss at Augsburg on Saturday as Sascha Moelder's first-half strike ended their record 53-game unbeaten league run.
Holders Bayern Munich eased into the German Cup third round with a comfortable 3-1 win at Hamburg SV on Wednesday to continue their unbeaten domestic run as they prepare for Saturday's league clash against Borussia Dortmund.
Bayern Munich and Barcelona registered easy wins, while Manchester United came from behind to beat CSKA Moscow 2-1 and Chelsea surrendered the top spot after a 1-1 at home against Atletico Madrid.
Angel Di Maria delivered a near-perfect performance, scoring two and setting up another as runaway leaders Paris St Germain beat 10-man Olympique de Marseille 3-1 at home on Sunday.
Images from the UEFA Champions League matches played on Tuesday.
A toothless and haggard Real Madrid slumped to a humiliating 10th Liga defeat of the season on Sunday as they lost 1-0 at struggling neighbours Rayo Vallecano.
Chelsea, Bayern Munich, Real Madrid and Juventus consolidated their top-flight leads at the weekend while Paris St Germain proved too strong for Ligue 1 leaders Olympique Marseille.
A round-up of Wednesday's league stage matches in the UEFA Champions League.
Manchester United's miserable season continued with a 3-2 home defeat by Galatasaray.
Roundup of the Champions League matches played on Wednesday night
Two late goals in two minutes from Sergi Roberto and Luis Suarez gave European champions Barcelona a dramatic 2-1 win over Bayer Leverkusen in the Champions League on Tuesday.
Borussia Dortmund steam-rollered hapless Freiburg 5-0 while Bayern Munich plodded past VfL Wolfsburg 1-0 as the two unbeaten arch-rivals remained level on points at the top of the Bundesliga on Saturday.
Barcelona extended their LaLiga lead to eight points thanks to second-half goals by Jordi Alba, Gavi and Raphinha that gave them a 3-0 home win against Sevilla
A summary of Wednesday's matches in the UEFA Champions League.
Images from the UEFA Champions League matches played on Wednesday
Bayern Munich put upstarts RB Leipzig firmly in their place by sweeping to an emphatic 3-0 home win, with all the goals coming in the first half, in a disappointingly one-sided top-of-the-table Bundesliga clash on Wednesday.
A summary of Wednesday's action in the Champions League quarter-finals first leg.
La Liga leaders Real Madrid cruised to a 4-0 home win over relegation-threatened Celta Vigo on Sunday to restore their seven-point lead at the top of the table with a dominant display.
Alexis Sanchez had equalised for the visitors, scoring on the rebound after Manuel Neuer saved his 30th-minute penalty but the Gunners suffered when captain Laurent Koscielny limped off injured to leave the defence exposed.
Cristiano Ronaldo finally became the highest scorer in Real Madrid's history while Bayern Munich set a record for the greatest number of successive wins at the start of a season in the Bundesliga this weekend.
Atletico Madrid sealed top spot in Champions League Group D after second half goals from Frenchmen Kevin Gameiro and Antoine Griezmann but Napoli were held to a 0-0 Champions League draw at home by Dynamo Kiev.
Robert Lewandowski scored a brilliant free kick to give Bayern Munich a 1-0 win over Atletico Madrid in their last Champions League Group D outing on Tuesday, ending the 100 percent record of their opponents. The Poland international curled the ball over the wall and into the corner of the net in the 28th minute but the goal had no impact on the final standings with Atletico guaranteed top spot and Bayern in second place.
Bayern Munich edged past Werder Bremen 2-1 on Saturday for a Bundesliga record 13th consecutive win over them to stay three points clear at the top of the table.
News of all that's transpired on and off the football field
